Sunday, April 26, 2015

Why There's Nothing "Extraordinary" In Claims Of GMO/Pesticide harm



“Extraordinary claims require extraordinary evidence.”

No shit, Sherlock?  This saying of Marcelo Truzzi has become a mantra for GMO advocates, to be used reflexively whenever anyone produces a substantive piece of empirical anti-GMO evidence.  And at first blush it sounds like a no-brainer.   OF COURSE extraordinary claims require extraordinary evidence!  And so far as I know, no-one has tried to deconstruct the adage.

Specifically, nobody seems to have pointed out the presupposition in the minor premise—that any claim of actual or potential damage from GMOs is of its very nature an extraordinary claim.  It is a presupposition devoid of any rational support.  Indeed ignoring this fact invokes another well-known adage: “Those who cannot remember the past are condemned to repeat it.”

The rationale for believing that claims of harm from GMOs are “extraordinary” lies in repeated statements by both government bodies and scientific organizations that GMOs are “safe”.  People apparently cannot remember that DDT, cigarette smoking, thalidomide, diethylstilbestrol and Agent Orange were all declared to be safe, often by the same organizations that have declared GMOs and the spraying of herbicide resistant plants to be safe--e.g. the FDA, which has consistently approved these, also approved thalidomide (1941) and diethylstilbestrol (1947).   The company that made Agent Orange, Monsanto, is the company that pioneered the use of glyphosate and that originally manufactured Agent Orange, whose supposedly less lethal component, 2, 4D, is now allowed to be used on pesticide-resistant crops produced by Dow AgroSciences.  And bear in mind that only two of the five cases noted (DDT, Agent Orange) involved substances that, like GMO pesticides, were actually intended to destroy living organisms.

I’ve had personal experiences with three of these cases, so I remember.  I smoked until I was forty, as a direct result of which I have severe emphysema, and several members of my wife’s family died from smoking-related conditions; they were all lifelong, heavy smokers.  I remember having a violent argument with an old friend, a well-known and highly respected geneticist, who swore by all that was holy that Agent Orange did no harm to humans; she, with all her credentials, was wrong, and I was right.  My beloved mother-in-law was killed in less than two years by doctors who, believing in the FDA’s assurance that diethylstilbestrol was appropriate for the treatment of menopausal symptoms, prescribed it and gave her cervical cancer.

If we look beyond the bland reassurances of industrial and government organizations, we see that the scientific work supposed to guarantee the safety of GMOs and pesticides is hopelessly out-of-date and unreliable.  The mantra on which such studies are based is, of course, “The dose makes the poison”, a doctrine originated by a sixteenth-century alchemist and astrologer.  How people who consider themselves scientists and regard their opponents as unscientific or actively anti-science can embrace a six-hundred-year old doctrine by a practitioner of two pseudo-sciences is a total mystery to me.  Do they also believe in Ptolemaic epicycles, the four humors, spontaneous generation?  That would be logical, since these equally formed part of cutting-edge sixteenth-century science.

The only reason for continuing to believe that “the dose makes the poison” is that this piece of pseudo-science supports the pro-GMO case and the real science doesn’t.  For what real scientists think, here’s the Endocrine Society’s take on it:

“Over the last two decades there has been burgeoning scientific evidence based on
field research in wildlife species, epidemiological data on humans, and laboratory
research with cell cultures and animal models that provides insights into
how EDCs cause biological changes, and how that may lead to disease. However,
endocrinologists now believe that a shift away from traditional toxicity
testing is needed. The prevailing dogma applied to chemical risk assessment is
that “the dose makes the poison.” These testing protocols are based on the idea
that there is always a simple, linear relationship between dose and toxicity, with
higher doses being more toxic, and lower doses less toxic. This strategy is used
to establish a dose below which a chemical is considered “safe,” and experiments
are conducted to determine that threshold for safety. Traditional testing involves
chemicals being tested one at a time on adult animals, and they are presumed
safe if they did not result in cancer or death.

“A paradigm shift away from this dogma is required in order to assess fully the
impact of EDCs and to protect human health. Like natural hormones, EDCs
exist in the body in combination due to prolonged or continual environmental
exposures. Also like natural hormones, EDCs have effects at extremely low doses
(typically in the part-per-trillion to part-per-billion range) to regulate bodily
functions. This concept is particularly important in considering that exposures
start in the womb and continue throughout the life cycle. A new type of testing is
needed in order to reflect that EDCs impact human health even at the low levels
encountered in everyday life."

And who or what is the Endocrine Society?  Some soft-on-science, anti-vaccine activist group, doubtless?  Well, as a matter of fact, no.


The Endocrine Society is a professional, international medical organization in the field of  endocrinology and metabolism founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed to The Endocrine Society on January 1, 1952. It is a leading organization in the field and publishes four leading journals. It has more than 17,000 members from over 100 countries in medicine, molecular and cellular biology, biochemistry, physiology, genetics, immunology, education, industry and allied health. The Society's mission is: ‘to advance excellence in endocrinology and promote its essential and integrative role in scientific discovery, medical practice, and human health’.  It is said to be ‘the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology.’”

So, to sum up: the GMO/pesticide nexus is just one of a series of cases within the last century where not only scientists but government agencies tasked with consumer protection have assured us certain products were safe until mounting death-tolls proved to everyone that they were wrong.  Now one of the world’s largest organizations in the relevant scientific fields has demonstrated that the grounds on which the “safety” of GMOs and their associated pesticide use are invalid.  Endocrine-disruptor doses “in the part-per-trillion to part-per-billion range” are unavoidable when “an estimated 85 percent of all food consumed in the United States now contains genetically modified organisms”.  For many pesticides used routinely on GMO crops, including what is by far the commonest, glyphosate, are endocrine disruptors.

Now can you please explain to me exactly how and why the claim that GMOs and pesticides may be damaging to our health is an extraordinary claim?

Because of course it is NOT an extraordinary claim.  In light of both the regulatory history of recent decades and the latest scientific findings in the most relevant field, it is, to the contrary, an extraordinarily ordinary claim.  And ordinary claims require only ordinary evidence—nothing more.  Like the kind of epidemiological evidence that blew the whistle on the smoking-lung cancer link.  Like the epidemiological evidence in Swanson et al., against which I am still waiting to hear a single substantive negative argument.

Wednesday, April 15, 2015

Betrayed By Your Favorite News Source--NPR LIED!



WITHOUT COMMENT.....


THE LIE:



March 24, 2015 3:48 PM ET
By Dan Charles.

Glyphosate residues on food, however, are not of great concern. The chemical is typically used in the early stages of growing crops like soybeans, corn, and canola. Those crops, if they even reach human consumers at all, are heavily processed first, destroying any glyphosate residues.

 THE TRUTH;

Clarification of Pre-harvest uses of glyphosate: The advantages, best practices and residue monitoring.

In several north western European countries glyphosate can be applied before crop harvest for weed control, to enhance ripening on non-determinate crops to reduce crop losses, and to help manage determinate crops in wet seasons… Glyphosate is absorbed by the leaves and stems of plants and is translocated throughout the plant… Glyphosate is slower acting but tends to reduce pod shatter, while helping the crop stems dry out to help harvest... Pre-harvest use of glyphosate started in 1980 (O’Keeffe, 1980) and revolutionized perennial weed control.

FROM: Arregui, M. C., Lenardón, A., Sanchez, D., Maitre, M. I., Scotta, R., & Enrique, S. (2004). Monitoring glyphosate residues in transgenic glyphosateresistant soybean. Pest Management Science, 60(2), 163-166.

In soybean leaves and stems, glyphosate residues ranged from 1.9 to 4.4mgkg and from 0.1 to 1.8mgkg in grains.

Tuesday, April 14, 2015

The Strongest Argument Yet for GMO labeling laws



So far, GMO supporters have managed to frame the GMO labeling controversy as a battle between pro-science and anti-science, and by and large they've been able to get away with it.  That’s been a key factor in the battles over labeling laws, most of which the anti-GMO side has lost.  Undecided voters may be unsure of science or even vaguely afraid of it, but they respect it and don’t want to be on the wrong side of it.

The only thing that will change this is showing them that scientific opinion is turning against GMOs and that all the dangers that have been pooh-poohed by GMO advocates are turning out to be real.  And now, thanks to two ground-breaking announcements that have come just in the last week or two, it’s possible to build a coherent argument that the GMO advocates won’t be able to answer.  The first is the decision by a WHO panel of experts that glyphosate is “probably carcinogenic”. The second, and to my mind the more important, is the Endocrine Society’s statement that glyphosate is an endocrine-disrupting chemical, capable of causing far-reaching and long-lasting damage to hormones essential for health.   These findings should be spread as far and as wide as possible, especially in areas where labeling laws and other restrictions on GMOs/pesticides are being proposed and have not yet been defeated.  The argument goes along these lines:


  •       The plants used in many GMO foods are RoundUp-resistant, and therefore have been sprayed with, and absorbed, glyphosate, a herbicide in the next-to-worst category of toxic substances by EPA standards.
  •        Yet GMO advocates tell us that scientists (with few or no exceptions) agree that this process is perfectly safe.  But that’s no longer true—if it ever was.
  •        The Endocrine Society, a hundred-year-old organization of scientists with 17,000 members, has just issued a statement naming glyphosate as an endocrine-disrupting chemical—that is, a substance that can cause far-reaching and permanent damage to the production of hormones vital for human health. 
  •       Consequently, government has both a duty and a responsibility to provide consumers with the power to decide whether or not they will buy food that might do them serious harm.   

UPDATE (04/16/15)
Will this argument work?  Since posting this I've been testing it on the Biofortified blog, one of the top pro-GMO blogs--the post in question is "Should science be a democracy?" So far there's been no attempt to answer it.  Maybe they can’t answer it. Maybe they daren’t admit, even to themselves, that they’re losing the “We’re the pro-science side” argument.  Follow it, it's fun.  
 

Saturday, March 28, 2015

How the medical establishment caused the anti-vaccination movement.

I watched the PBS Frontline on the Vaccine Wars and they still don't get it, five years on.

In 2010 I blogged about their first "Vaccine Wars"for Psychology Today.   Five years later they're still ignoring both of the 500lb gorillas in the room.  And refusing to admit what should be blindingly obvious to any unbiased observer--the main cause of the belief that vaccines cause autism lies not with parents' hysterical fears or ignorance of 'REAL science' but with the medical establishment's gross stupidity (if it's no worse than that) in dealing with autism.

Look, John, see the gorillas!  Gorilla Number One is something that Frontline admitted in a quick screen flash that was over, wholly without comment, in a couple of seconds--that autism has increased by a whopping 6000% over the last few decades.  Gorilla Number Two is the fact that they and the medical establishment continue to completely ignore: that there are two kinds of autism,  one clearly genetic and unvarying from the start, the other occurring in previously normal children and triggering rapid regression to an autistic state.  Obviously something in the environment is implicated in these cases.  But what?

Clearly the two gorillas are related.  Evil twins.  If autism has soared and if a lot of it (how much, nobody knows--talk about that for neglect of responsibility!) consists of late-onset, regressive autism, part of the cause has to be something in the environment that wasn't present before.  The obvious move for any responsible medical establishment is to start looking for the new factor(s).

Did they?  Not for one second.  They blandly told us that the increase was due to broader diagnostic criteria, better diagnosis, wider public awareness.  The regressive autism cases?  Well, that was just that the parents were in denial until they were eventually forced to face the truth--their "kids" had been autistic all along but they hadn't recognized it.

I don't like it when people insult my intelligence.  I get apoplectic when those people masquerade as the voice of REAL science. What the medical establishment offers is not even junk science.  It's nothing more than the face-saving reaction of any large human organization, which is always self-protective and always strives to pass itself off as omniscient.  If doctors are the all-knowing guardians of our health that they think they are, how can they say that they don't have a clue about what's causing the staggering increase in autism?

So they pretend that the causes are what they've always been--strictly genetic--and that therefore there hasn't REALLY been an increase, and that if you think there has, you're an ignorant idiot.   Which is absolute self-serving crap, as anyone with half a brain can see.  Can you imagine how a parent feels who has just seen a bright and promising toddler with a whole fruitful and happy life ahead of him or her suddenly regress to a prelingual presocial state, maybe just days or weeks after a vaccination (or more likely, with today's protocols in place, a whole batch of vaccinations, some against diseases you're unlikely ever to see, but Big Medicine's mantra is CAN DO, WILL DO).  What would you think?  Oh no it can't be the vaccine because a man  in a white coat told me it wasn't?

So the anti-vaccine movement is the natural and inevitable reaction of any normal human to the cretinous obstructionism of the medical establishment.  You broke it, you doctors--now go fix it!

The medical establishment could fix the anti-vax movement by simply telling the truth.  By saying, loud and clear:  yes, we're sorry, we dropped the ball on this one, but clearly there's something new at work here, and it's almost certainly something in the environment, so we're going to work our butts off finding out what it is, no holds barred--and, parents of autistic children, we welcome any input you can give us!

Will they?  Come on, what world are you living in?

A funny world indeed, where police work is more scientific than science.  I kid you not.  Faced with a crime where there's no obvious suspect, a good detective doesn't say, "Oh well, maybe it didn't happen".  A good detective suspects everyone until s/he has a prime suspect (or at least a "person of interest") in sight.  A good detective doesn't rule out any possible suspect unless that suspect can supply an unbreakable alibi.  Even if s/he can't solve the case, a good detective never, ever gives up--sometimes, not even after retirement.  Those are just the things that a good scientist should always do.  And what a frightening number of self-described scientists today wouldn't even dream of doing.

Me, I don't rule out anything.  Vaccines are relatively low on my list of suspects. PCBs somewhere in the middle.  Pride of place: pesticides, and genetically engineered foods that have been exposed to pesticides.  Of course, now we are realizing there are wide differences in individual reactions, it could be multi-causal.  But pesticides are the prime suspects, because the UC Davis study showed that pregnant women in sprayed areas were 60% likelier to have autistic  children and because the Swanson et al. paper showed an R = 0.989 for the autism-GMO/glyphosate connection.

It's high time to get the show on the road.  I'm already preparing a list of all the leading U.S. science writers and editors who will shortly receive an open letter asking them why they have abdicated their responsibility to the American public and failed to publicize the great and growing threat that the monstrous increase in the use of glyphosate and other pesticides poses to us all.

Saturday, March 21, 2015

HOT, HOT BREAKING NEWS! The Lancet Declares Glyphosate “Probably Carcinogenic to Humans”!!!



Talk about smoking guns!  This is more like a fusillade from an AK-47!

Yesterday, the prestigious, ultra-conservative medical journal The Lancet reported, pre-publication, on a study produced by 17 experts from 11 countries on the carcinogenicity of five leading pesticides, scheduled to appear as Volume 112 of a series of monographs produced by IARC (the International Agency for Research on Cancer, Lyon, France).  Herewith, complete and unexpurgated, is The Lancet’s summary of what the monograph says about glyphosate.  Any italics in the summary are mine.

“Glyphosate is a broad-spectrum herbicide, currently with the highest production volumes of all herbicides.  It is used in more than 750 different products for agriculture, forestry, urban, and home applications. Its use has increased sharply with the development of genetically modified glyphosate-resistant crop varieties.  Glyphosate has been detected in air during spraying, in water, and in food.  There was limited evidence in humans for the carcinogenicity of glyphosate. Case-control studies of occupational exposure in the USA, Canada, and Sweden reported increased risks for non-Hodgkin lymphoma that persisted after adjustment for other pesticides. The AHS cohort did not show a significantly increased risk of non-Hodgkin lymphoma. In male CD-1 mice, glyphosate induced a positive trend in the incidence of a rare tumour, renal tubule carcinoma. A second study reported a positive trend for haemangiosarcoma in male mice.  Glyphosate increased pancreatic islet-cell adenoma in male rats in two studies. A glyphosate formulation promoted skin tumours in an initiation-promotion study in mice.  

“Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans.  Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro. One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations.  Bacterial mutagenesis tests were negative. Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro. The Working Group classified glyphosate as “probably carcinogenic to humans” (Group 2A).”

All right, all you guys who have scoffed at Nancy Swanson and her colleagues.  Let’s see what you have to say to THAT!